1,5,7-Triazabicyclo[4.4.0]dec-5-ene TBD CAS 5807-14-7

1,5,7-Triazabicyclo[4.4.0]dec-5-ene TBD CAS 5807-14-7

1,5,7-Triazabicyclo[4.4.0]dec-5-ene (TBD), with CAS number 5807-14-7, is a bridged guanidine-based strong base. It can be used as an organic synthesis intermediate and a pharmaceutical intermediate. The rigid bridged guanidine framework has a strong base property and good organic solubility, which is different from inorganic bases and is suitable for fine organic synthesis catalysis.

Catalytic properties
Highly active organic catalysts: capable of catalyzing various reactions such as ring-opening polymerization, condensation, addition, ester exchange, and ring addition
Suitable for controlled polymerization, enabling precise regulation of the structure and molecular weight of degradable polyesters and other high-molecular substances
Can be made into immobilized versions, facilitating recovery and reuse

Specification

Application

1. Organic Synthesis Catalysis
1,5,7-Triazabicyclo[4.4.0]dec-5-ene (TBD) acts as an extremely strong organic base catalyst, facilitating various fine organic reactions such as Michael addition, Henry reaction, condensation reaction, Wittig reaction, HWE eneification reaction, ester exchange, amide formation, cycloaddition, and cyclization, enabling the formation of C-C and C-N chemical bonds under mild conditions.
Synthesis of drug intermediates, heterocyclic compounds, and chiral compounds, as well as research and production of pharmaceutical raw materials and processes
Deprotonating reagents, activating acidic C-H bonds, phenols, and carboxylic acid substrates, to enhance reaction selectivity and yield
2. Polymer Material Synthesis Catalysis
Ring-opening polymerization (ROP) of monomers such as cyclic esters, esters, and epoxides, to prepare degradable polyester materials like polylactic acid and polycaprolactone, and to control molecular weight and microstructure
Non-isocyanate polyurethanes (NIPU), thermosetting resins, vitrimers dynamic covalent materials, and catalysis for polyurethane/epoxy curing, to improve the mechanical and heat resistance properties of materials
Catalysis for the synthesis and modification of polymers such as organosilicon and polyamide
3. Green Conversion and Capture of Carbon Dioxide
CO₂ fixation, catalysis of ring addition, to synthesize green chemicals such as cyclic carbonates for carbon resource utilization
CO₂ adsorption materials, reversible capture systems, to achieve carbon capture and regeneration
4. Fine Chemicals
Synthesis catalysis for fine chemicals, coating / adhesive systems
5. Others
Preparation of immobilized TBD catalysts for continuous reactions, separation and purification, alkaline scavengers, etc.

Packaging

25kg/drum

Storage

Storage: Store in a sealed, dry environment protected by an inert atmosphere (nitrogen / argon), kept in a cool place, protected from moisture and acids.
Safety: Strongly corrosive chemicals. Wear goggles, acid-resistant gloves and protective clothing throughout the process; avoid direct contact with strong acids; in case of accidental contact, rinse immediately with plenty of water and seek medical attention.